Systems Pharmacology and Synthetic Neuro-genetics
    --- Molecular Assembly and Genes Regulated Network Involved in Cytogenesis and Pathogenesis ---

    -Zoology - Genetics and Transgenics

Systems Medicine - Systems and Synthetic Biology
EDUCATION & EXPERIENCE
2008-Present: Principal Investigator, Director of Benjoe Institute of Systems Bio-Engineering, Changzhou, PR. China.
1997-2006: Research Fellow, Grant-holder of SPARKS Fund, University of Birmingham, UK. Research Scientist, Institute for Animal Breeding, FAL, Germany. Research & Ph. D. Scholarship, Sheba Medical Center of University of Tel-Aviv, Israel.
2003-2004: Director of academic division, Chinese Student and Scholar Association in Birmingham, UK.
1994- 1997: Assistant Professor, Gene Engineering Technology Center, Institute of Microbiology, CAS, Beijing, PR. China. Beijing Biotech Demo Centre of Beckmann Inc. - Consultant and Advertising Design for Biological Instruments.
Nov. 18-23, 1996: Secretary-General, 1st International conference on transgenic animals, Beijing, PR. China.
1985-1994: Visiting Student of Pharmacognacy in 1990, at the China Pharmaceutical University, Nanjing, P. R. China. Lecturer of Cell Biology and Medical Genetics ¨C the Medical School of Xiangtan Institute of Technology, Hunan Agricultural University at Hengyang, Hunan, PR.China.
In 1992: Due to the articles on System Medicine and Pharmacology, Awarded Excellent Researcher of Medical Science and Technology for decade, Xiangtan city, China.
1981-1985: Study Zoology and Cytogenetics, Xiamen University (national key university), Fujian, P.R. China.
In 1983, wrote the Structurity ¨C Pan-evolution Theory included two articles - 1) On sense organs evolution of animals during ecological adaptation, 2) The structure theory view on the evolution of biological structure-function relations.
BIOTECHNOLOGY & BIOINFORMATICS
1). Bioinformatics, Homologous Analysis of Genes
2). Oligoes, PCR Primers, Probes, Gene Fragments Computer Aid Design
3). Synthesis of Total Gene by Using of DNA Fragments in Vitro
4). Detection of DNA Site Mutation, Gene Diagnosis
5). Gene Recombination, Gene Cloning, DNA Sequencing
6). Southern, Northern (MD-SF 130 Phosphor-imager) Hybridization
7). Promoter Analysis, RNA Interference, Gene Silencing
8). Quantitative and real-time RT-PCR (Lightcycler, Roch)
9). Mammalian Cell Culture Mutagenesis
10). Avian Embryo Manipulation, primary cell culture in vitro
11). Total Gene and Vector Construction, Reporter Gene Assay
12). Transgenic Techniques, Stable Protein Expression in Cell Lineage
13). Western Blotting, Protein Immunoprecipitation
14). Peptide Synthesis, Elisha Experiments and Statistical Analysis
15£©mRNA Differential Display, cDNA micro-Arraying (GenePix 4000B) etc.

    Systems and synthetic biology, are the science and engineering of bio-systems by using integrative methodology of systems approaches, experimental technology, computational bioinformatics, and engineering biology at the levels of molecular and cellular bio-systems.
    Systems genetics is the cross-discipline to study the expression patterns of genotype-phenotype complexity, non-linear cell dynamics, genomic stability and evolution of organogenesis etc. During pattern formation, each independent complex trait of organism being controlled by synergic expression of gene group (multi-genes),and forms a functional or morphogenesis unit (module).
    Synthetic biology (systems bio-engineering) is the engineering discipline of genomic construction and systematic designing of molecular modules for artificial bio-systems used as bio-sensors, cell computer, bioreactor and cell factory, which involved in gene analysis, molecular drug screening, and transgenic expression of pharmaceuticals etc..
    We are studying of pharmacology and systems genetics for understand the evolution and development of neuro-endocrine network at the aspects: mutants of cell lineages, identified genes involved in cell differentiation and pathology of complex diseases.
    To understand the dynamics of genomic information, the genes regulatory network of genetic program and the bio-logic mechanism of bio-systems, the methods of and signaling biology, designing of bio-bricks of molecular modules, and synthesis of artificial cells will be used.

Structurity - the structure theory of bio-systems:
1).structure integration, coordinative organization of genes in genome, the independent phenotype is controlled by genes group (multi-genes).
To compare the genes organization in genome with the expression pattern of proteins, we try to understand the genetic logic of genomic maps. The biochemical metabolism, enzyme groups systems include the essential systems in original cells, adaptation systems in cell species, and program induced expression systems in tissue cells such as the neuron, endocrine, immune and vascular cells etc.
2).function adaptation, duplication (amplify) of cell genome, tissue-specific expression of genes and molecular modules, the expression of genes chain depends on the self-adaptation in molecular signals pattern of the tissue micro-environment.
The stable rhythm patterns of secretary molecules regulate gene expression in cells differentiation, proliferation and apoptosis includes: a). signaling dynamics and pattern formation, b). cell lineage mapping and organogenesis pattern, c). oscillation, morphogenesis and psychosomatic regulation etc.
The tissue cells are constructed in patterning of coherent body, cell cycle regulation and fate determination be controlled by secretary (hormones etc.) rhythms of signals.
3).construct stratification, recombination, multiple stratum structure of genome, the mutation in genes family of gene transpose, recombination and amplification.
Genomic stratified (mutation) construction - self-organization of genomic evolution, cellular mutation pattern and co-evolution of organisms. The artificial evolution is the transgenic and synthetic engineering of genome by using the mechanism of amplification, rearrangement of genes etc.
CONFERENCE
1. Zeng BJ. etc., A Brief View of Systems Medicine and Genetics, International Conference on Systems Medicine, Dublin, Sept.9-13-,2012.
2. Zeng BJ.etc., Systems Biology of Molecular Cytogenesis, The Structurity Theory of Molecular Biosystems for Cells Communication, 12th International Conference on Systems Biology, Heidelberg - Mannheim, Germany, Aug.28-Sept.1, 2011.
3. Zeng (B.) J.etc., Modular Designing and Synthesis of Cell Molecular Biosystems, 2011 Symposium£¨annual meeting£©,Cold Spring Harbor Asia Conferences, Suzhou, Nov. 7-11, 2011.
4. Zeng BJ., Systems Medicine and Pharmacy - Where West meet East, 11th International Conference on Systems Biology, Edinburgh, Oct.10-16,2010.
5. Zeng BJ., Applied Systems Genetics in Medicine and Engineering, 11th International Conference on Molecular Systems Biology, June 21-25,2009,Shanghai, China.
6. Zeng B. J. The Genetic Mechanism of Biosystem Patterns - Non-Linear Cell Dynamics, XX International Congress of Genetics, Berlin, Germany, July 12-17, 2008.
7. Zeng J., Structurity - Pan-Evolution Theory of Biosystems, The XXII World Congress of Philosophy, Seoul, Korea, July 30 - Aug.5 2008.
8. Zeng J. etc., Signal Transduction, Expression and Cloning of Genes Involved in Cytogenesis, Proceedings of the Forum on Genetics Progress and Population Health (Chinese), Nov.14-17, 2007.
9. Zeng J., Drug Discovery, Gene Isolation and Transgenic Systems Biotechnology, Returned Chinese Scholars Pioneering£¨Chinese£©, 2007 Oct.; (10):49.
10. Zeng, J., System Biological Engineering (item No. 2547, p109), the 9th Guangzhou Convention of Overseas Chinese Scholars in Science and Technology, Dec. 28-30, 2006.
11. Zeng B. J. The Third Wave of Genetics - Pattern Genetics, Melbourne, Australia, 19thICG, July6-11, 2003.
12. Zeng J., Self-Organization and Specific Expression of Genome, First International & Third National Conference on Transgenic Animals, Beijing 1996 Nov.18-23.
13. Zeng J. etc., Transgenic Chicken Used as Oviduct Bioreactor for pharmaceutical protein expression in the egg white, International Symposium and Exhibition on Pharmacy and Biotechnology, Shanghai, China, July 15-20, 1995.
14. Zeng J., The Rhythms Stability Model of Animal Development, 94-Symposium for Yong Chinese Developmental Biologists, Beijing, China, Oct. 10-15, 1994.
15. Zeng J., Pan-evolution Theory of Biosystems Self-organization, International Congress of Scientific Philosophy and Logic, Wuhan University, Oct. 2-7, 1993.
 PUBLICATIONS
16. Zeng XX, Zeng JB., Systems Medicine as a Strategy to Deal with Alzheimer's Disease. J Alzheimers Dis. 2023;96(4):1411-1426. doi: 10.3233/JAD-230739.
17. Zeng J., Zeng XX., Systems Medicine for Precise Targeting of Glioblastoma. Mol Biotechnol.2023 Oct;65(10):1565-1584.doi: 10.1007/s12033-023-00699-x.Epub 2023 Mar 1.
18. Zeng BJ.,Systems Genetics and Biotechnology - Analysis and Synthesis of Cell Molecular Biosystems. Biotechnology Bulletin£¨Chinese£©, 2012,No.12.
19. Zeng BJ., Systems Biology and Systems Dynamics of Cytogenesis, J.Biology£¨Chinese£©£¬2011,No.5.
20. Zeng BJ., Molecular Systems Biology and Dynamics of Cytogenesis, Biotechnology Bulletin£¨Chinese£©, 2011, No.8.
21. Zeng Bj., Applied Systems and Synthetic Biology in Micro-Fluidic Biochips, NSTI Nanotech. Conference and Expo, P.508-511, Vol. 2, Nanotechnology 2010, Published: June 21,2010.
22. Zeng BJ., Applied Systems Genetics and Sequence Tagged Fragments Display Analysis of Gene Regulatory Network Involved in Cytogenesis, Biotechnology Bulletin£¨Chinese£©, 2010, No.1.
23. Zeng BJ., Biotechnology of Drug D iscovery Involved in Anti2apoptosis PI3K Signal Transduction£¬Biotechnology Bulletin£¨Chinese£©, 2009, No.8.
24. Zeng J., System Genetics and Synthetic Biology - the 21th Century Science and Engineering, Biotechnology Bulletin £¨Chinese£©, 2008 May; No.(5).
25. Zeng J., Synthetic Biology and Transgenic Systems Biotechnology, Proceedings of IBS2008, Journal of Biotechnology 136S,1 Oct.2008.
26. Zeng J., The Pattern Genetics and Modern Systems Biotechnology, Biotechnology Bulletin £¨Chinese£©, 2007 Jan; (1):1-5.
27. Zeng J. etc., Industrialization of High Scientific Technology of System Biological Science and Engineering, Biotechnology Bulletin£¨Chinese£©, 2006 Dec.; (6):1-4.
28. Zeng J., P. Aldag etc., Signal Transduction Mediating Gene Activation of SP1, LH?-subunit and GH in Response to GHRH or GnRH in the Postnatal and Fetal Porcine Anterior Pituitary in Vitro (& Cloning of Egr-1/NGFI-A cDNA sequence - Genbank AJ238156), Exp Clin Endocrinol Diabetes. 2005 Jan; 113(1):21-30.
29. Zeng J., The Fundamentals and Applications of Transgenic Animals, Biotechnology Bulletin £¨Chinese£©, 1997 Dec.; (6):13-18.
30. Zeng J., From Positive to Synthetic Medical Science, Communication on Transgenic Animals, CAS, Vol.2, No.11, 1995.
31. Zeng J., The Expression System of Transgenic Animals - Transgenic Gold-egg Plan (system genetics), Communication on Transgenic Animals £¨Chinese£©, CAS, Vol. 1, No. 11, 1994.
32. Zeng J., On the Category of System Biological Engineering, Communication on Transgenic Animals£¨Chinese£©, CAS, Vol. 1, No.6, 1994.
33. Zeng J. etc., Neuro-Endocrine and Gene Regulation Involved in Mammalian Morphogenesis, First Congress of Young Scientists of Hunan Province Association for Science and Technology £¨Chinese£©, Hunan Science and Technology Press, 1992.
34. Zeng J. etc., On the Holographic Model of Human Body (system medicine and pharmacology), First Conference on Comparative Studies Traditional Chinese Medicine with Modern Medicine, Medicine and Philosophy£¨Chinese£©, Apr. 7-11, 1992.
35. Zeng J., On the Structure of Science and the Future of China (systems science, AI and genetic engineering), Natural Information£¨Chinese£©, No. 5 (1), 1991.
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