The progressive differentiation and mapping of distinct cell lineages from a common primordium involves a series of developmental decisions and inductive interactions during organogenesis. The phenotype development of the cell lineages occur as the result of a complex synergistic or competitive regulation among numerous factors inducing or inhibiting the expression of genes. The purpose of this long-term investigating is to charaterize the ontogenetic mechanisms of cell phenotypes, patterning responsiveness to signal and molecular clock regulation in vivo embryo development or in vitro tissue culture. The neuron, endocrine, immune and circulatory cells are specificated cell patterns derived from ectoderm, endoderm and mesoderm of animal embryo. Among these cells have specific receptors for cell communicating and signal transduction. The cells are organized in spatiotemporal pattern of developing which regulated by secretory rhythm of signals and genomic program expression of genes. The developing patterns of main, collateral channels (Chinese Traditional Medicine) are the cross signaling through the immune, neuro-endocrine systems, and take active roles in the psychsomatic regulation of morphogenesis.