Biosystem Science and Engineering

Systems Biology
In 1968, D.Mesarovic proposed at the Conference on Systems Theory and Biology, that Bertalanffy adopted the concept of the terminology of "organism biology" and methods of systems theory; R.Rosen developed mathematical biology methods; and in 1999, B.J. Zeng adopted "systems bioscience and defined it as the study of bio-systems using the methodology of theoretical, experimental, and computational biology.
Synthetic Biology
In 1910, S.Leduc proposed it in physical chemistry; in 1974, W.Szybalski and in 180, B.Hobom formulated it as genetic recombination technology; in 2000, E.Kool redefined it as chemical synthesis of artificial xDNA; from 2001 to 2005, it was internationally discussed as engineering biology based on engineering design methods, namely, genetic engineering based on systems biology - the design, and synthesis of artificial bio-systems at the level of systems genetics as discussed by Bj. Zeng in 1994 regarding systems bio-engineering.
Systems Medicine and Pharmacology
In 1992, Bj.Zeng proposed in the comparison of Chinese and Western medical theories - that the complex system research of disease and drug treatments, cell communication and molecular networks, and the neuro-endocrine and immune networks constitute a "socio-psychological-biological" integrative medicine, which integrates system theory and experimental technology, software simulation and engineering models, and methods such as graph theory and network topology.
Systems Genetics
In 1994, BJ.Zeng proposed in evolutionary and developmental (Evo-Devo) biology of the "genotype-phenotype" system, genomic homeostasis and self-organization, genetic program expression and cell lineage mapping, as well as the biomorphology and cytogenetic dynamics of cell lineage mapping, including research on gene networks in stem cell differentiation and dedifferentiation; in 2003, at the 19th International Congress of Genetics, Bj.Zeng discussed the development of three paradigms in genetics.
Systems Bio-engineering and Biotechnology
In 1994, BJ.Zeng proposed the machine model of cellular automatics - an engineering approach based on systems biology and microelectronics, integrating artificial intelligence with genetic engineering, bionics with transgenic technology, and in 1999, the "biosystems engineering" with computer and software engineering methods to study cell design and artificial bio-systems; 2007-2011, computers and the internet were listed as the third industrial revolution, and discussed the fourth industrial revolution - in 2024, also named it as the third machine revolution.
And, with a concept consisting of interconnected three parts:
Part one: designing and synthesizing artificial cells using the thinking of computer and electronic technology, such as molecular module design and gene fragment assembly and synthesis;
Part two: designing software and chips for computers and nanomachines based on cellular molecular mechanisms, such as graph neural networks and neuro-biomimetic engineering;
Part three: how to connetct these two parts, which is the human-machine interface, such as neural engineering and virtual reality, etc.

Bj.Zeng's Exploration - Humanities and Science in Medical Development:
Childhood memories - Peony herbaceous garden, binoculars and kaleidoscope - From Wuhan grandfather and Shanghai grand-aunt, reading Chinese and Western medical books in 1972, family traditional culture education in 1976.
Structure Theory - Pan-evolution theory, 1-Cities groups and geoculturology - 4-axis era and 4-world theory, 2-Systems medicine and graph theory-network topology model - Synthetic and systems biology, bio-systems theory and artificial bio-systems design.
1991-1997, a- Systems bioengineering (analog) and bioelectronics, b- Systems genetics and transgenic oviduct and bionic engineering, c- Artificial intelligence and genetic engineering and artificial evolution - computational bioinformatics and experimental biotechnology, 1996-1999, organizing international conferences establishing the association - transitioning to the Bio-Systems Science and Engineering (BSSE) coupling mode.
2007-2010, Systems dynamics of cytogenesis - Neuron computer, nano-microfluidics and organic Robotics; 2023-025, Synthetic neurogenetics - alternative (xeno) consciousness and human-machine co-evolution.
Note:-
Terms Coined by Bj.Zeng, 1992 - Systems medicine, 1993 - Pan-evolutionary, 1994 - System genetics, Systems bio-engineering, Oviduct bioreactor, Cells bionic engineering, 2023 - Synthetic neurogenetics, 2024 - Xeno consciousness etc..